Literature summary for 3.4.21.79 extracted from

Quan, L.T.; Tewari, M.; O'Rourke, K.; Dixit, V.; Snipas, S.J.; Poirier, G.G.; Ray, C.; Pickup, D.J.; Salvesen, G.S.
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B (1996), Proc. Natl. Acad. Sci. USA, 93, 1972-1976.

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Protease CPP32 + H2O	granzyme B activates CPP32, which is now able to bind inhibitors and cleave the substrate poly(ADPribose)polymerase whose proteolysis is a marker of apoptosis initiated by several other stimuli	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)