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Literature summary for 3.4.21.77 extracted from

  • Kumar, S.; Gurshaney, S.; Adagunodo, Y.; Gage, E.; Qadri, S.; Sharma, M.; Malik, S.; Manne, U.; Singh, U.P.; Singh, R.; Mishra, M.K.
    Hsp70 and gama-Semino protein as possible prognostic marker of prostate cancer (2018), Front. Biosci., 23, 1987-2000 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
diagnostics the gama-SM/PSA, a protein member of the kallikrein family, is the most prominent biomarker for prostate cancer, PCa. Hsp70 can also be used as a co-biomarker for PCa with gama-SM Homo sapiens
drug development the gama-SM protein can be a drug target in prostate cancer therapy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-nitrophenyl boronic acid inhibits PSA Homo sapiens
alpha1-Antichymotrypsin inhibits PSA Homo sapiens
Boric acid inhibits PSA Homo sapiens
dutasteride inhibits PSA Homo sapiens
finasteride inhibits PSA Homo sapiens
norleucine inhibits PSA Homo sapiens
norvaline inhibits PSA Homo sapiens
Z-SSKL(boro)L inhibits PSA Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P07288
-
-

Synonyms

Synonyms Comment Organism
gama-SM protein
-
 Homo sapiens
prostate-specific antigen
-
 Homo sapiens
PSA
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the HSP protein family and the gama-SM protein are related in two critical ways: the fact that silencing HSPs may be directly correlated with reduced gama-SM protein expression and their high potential as biomarkers for PCa. A direct proportional relationship between Hsp70 and the gama-SM protein Homo sapiens