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Literature summary for 3.4.21.77 extracted from

  • Kojtari, A.; Shah, V.; Babinec, J.S.; Yang, C.; Ji, H.F.
    Structure-based drug design of diphenyl alpha-aminoalkylphosphonates as prostate-specific antigen antagonists (2014), J. Chem. Inf. Model., 54, 2967-2979.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information structure-based drug design of diphenyl alpha-aminoalkylphosphonates as prostate-specific antigen antagonists, overview. Molecular docking and modeling of covalent and noncovalent binding of this class of inhibitors, interactions between the lead compound and residues Thr190, Ser217, and Ser227 in the P1 pocket Homo sapiens
R/S-diphenyl[N-benzyloxycarbonylamino(4-carbamoylphenyl)methyl]phosphonate
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P07288
-
-

Synonyms

Synonyms Comment Organism
prostate-specific antigen
-
Homo sapiens
PSA
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00025
-
pH and temperature not specified in the publication Homo sapiens R/S-diphenyl[N-benzyloxycarbonylamino(4-carbamoylphenyl)methyl]phosphonate

General Information

General Information Comment Organism
physiological function the enzyme is responsible for the advancement of prostate tumor progression Homo sapiens