Literature summary for 3.4.21.77 extracted from

Li, Y.; Tian, Y.; Rezai, T.; Prakash, A.; Lopez, M.F.; Chan, D.W.; Zhang, H.
Simultaneous analysis of glycosylated and sialylated prostate-specific antigen revealing differential distribution of glycosylated prostate-specific antigen isoforms in prostate cancer tissues (2011), Anal. Chem., 83, 240-245.

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Application

Application	Comment	Organism
medicine	mass spectrometry-based analytical method to measure different glycosylated forms of glycoproteins from complex biological samples by coupling glycopeptide extraction strategy for specific glycosylation with selected reaction monitoring SRM. Using this method, glycosylated and sialylated prostate-specific antigen PSA in prostate cancer and noncancer tissues can be monitored. The relative abundance of glycosylated PSA isoforms is not correlated with total PSA protein levels measured in the same prostate cancer tissue samples by clinical immunoassay. The sialylated PSA is differentially distributed in cancer and noncancer tissues, and elevated in cancer tissues compared to noncancerous tissues	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	the relative abundance of glycosylated PSA isoforms is not correlated with total PSA protein levels measured in the same prostate cancer tissue samples by clinical immunoassay. The sialylated PSA is differentially distributed in cancer and noncancer tissues, and elevated in cancer tissues compared to noncancerous tissues	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
prostate	-	Homo sapiens	-
prostate gland cancer cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)