Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of the enzyme expression in C8161.9, MelJuSo, and HeLa cells by shRNA | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
a1-PDX | - |
Homo sapiens | |
Dec-RVKR-CMK | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09958 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C8161.9 cell | - |
Homo sapiens | - |
HEK-293 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
MDA-MB-435 cell | - |
Homo sapiens | - |
MelJuSo cell | - |
Homo sapiens | - |
additional information | the enzyme is constitutively expressed in all cell lines. No enzyme activity in LoVo colorectal carcinoma cells | Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the proprotein convertase family of proteases | Homo sapiens |
malfunction | knockdown of the enzyme expression in C8161.9, MelJuSo, and HeLa cells by shRNA leads to reduced or complete loss of KISS1 processing | Homo sapiens |
physiological function | furin is involved in the secretory pathway. It is the major proprotein convertase required for KISS1-to-kisspeptin processing. KISS1 is a broadly functional secreted proprotein that is then processed into small peptides, termed kisspeptins | Homo sapiens |