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Literature summary for 3.4.21.75 extracted from

  • Harihar, S.; Pounds, K.M.; Iwakuma, T.; Seidah, N.G.; Welch, D.R.
    Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing (2014), PLoS ONE, 9, e84958.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information knockdown of the enzyme expression in C8161.9, MelJuSo, and HeLa cells by shRNA Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
a1-PDX
-
Homo sapiens
Dec-RVKR-CMK
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P09958
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C8161.9 cell
-
Homo sapiens
-
HEK-293 cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-
MDA-MB-435 cell
-
Homo sapiens
-
MelJuSo cell
-
Homo sapiens
-
additional information the enzyme is constitutively expressed in all cell lines. No enzyme activity in LoVo colorectal carcinoma cells Homo sapiens
-

General Information

General Information Comment Organism
evolution the enzyme belongs to the proprotein convertase family of proteases Homo sapiens
malfunction knockdown of the enzyme expression in C8161.9, MelJuSo, and HeLa cells by shRNA leads to reduced or complete loss of KISS1 processing Homo sapiens
physiological function furin is involved in the secretory pathway. It is the major proprotein convertase required for KISS1-to-kisspeptin processing. KISS1 is a broadly functional secreted proprotein that is then processed into small peptides, termed kisspeptins Homo sapiens