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Literature summary for 3.4.21.75 extracted from

  • Yang, X.; Wang, Q.; Gao, Z.; Zhou, Z.; Peng, S.; Chang, W.L.; Lin, H.Y.; Zhang, W.; Wang, H.
    Proprotein convertase furin regulates apoptosis and proliferation of granulosa cells in the rat ovary (2013), PLoS ONE, 8, e50479.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
granulosa cell primary Rattus norvegicus
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additional information furin is highly expressed in granulosa cells and oocytes of the ovary with very limited expression in other ovarian cells such as the epithelial, stromal or theca cells Rattus norvegicus
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oocyte
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 Rattus norvegicus
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ovary
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 Rattus norvegicus
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General Information

General Information Comment Organism
evolution furin is a member of the subtilisin-like proteases and belongs to the proprotein convertase subtilisin/kexin-like proteases, subgroup PCSK3 Rattus norvegicus
malfunction furin siRNA significantly increases apoptosis of the granulosa cells from large antral/preovulatory follicles, in part via downregulation of the anti-apoptotic proteins, XIAP and p-AKT. On the contrary, furin siRNA markedly decreases proliferation of granulosa cells based on the downregulation of proliferation cell nuclear antigen Rattus norvegicus
metabolism the enzyme activates large numbers of proprotein substrates and is ubiquitously expressed and implicated in many physiological and pathological processes Rattus norvegicus
physiological function furin may play an important role in regulating apoptosis and proliferation of granulosa cells, role of furin in the development of granulosa cells during folliculogenesis, overview Rattus norvegicus