Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
granulosa cell | primary | Rattus norvegicus | - |
additional information | furin is highly expressed in granulosa cells and oocytes of the ovary with very limited expression in other ovarian cells such as the epithelial, stromal or theca cells | Rattus norvegicus | - |
oocyte | - |
Rattus norvegicus | - |
ovary | - |
Rattus norvegicus | - |
General Information | Comment | Organism |
---|---|---|
evolution | furin is a member of the subtilisin-like proteases and belongs to the proprotein convertase subtilisin/kexin-like proteases, subgroup PCSK3 | Rattus norvegicus |
malfunction | furin siRNA significantly increases apoptosis of the granulosa cells from large antral/preovulatory follicles, in part via downregulation of the anti-apoptotic proteins, XIAP and p-AKT. On the contrary, furin siRNA markedly decreases proliferation of granulosa cells based on the downregulation of proliferation cell nuclear antigen | Rattus norvegicus |
metabolism | the enzyme activates large numbers of proprotein substrates and is ubiquitously expressed and implicated in many physiological and pathological processes | Rattus norvegicus |
physiological function | furin may play an important role in regulating apoptosis and proliferation of granulosa cells, role of furin in the development of granulosa cells during folliculogenesis, overview | Rattus norvegicus |