Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis | Pteropus alecto |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
decanoyl-Arg-Val-Lys-Arg-chloromethyl ketone | - |
Pteropus alecto |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | furin is primarily located in the Golgi and trans-Golgi network, and it can also circulate between the cell surface and the trans-Golgi network | Pteropus alecto | 5794 | - |
trans-Golgi network | - |
Pteropus alecto | 5802 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Pteropus alecto |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pteropus alecto | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Pyr-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin + H2O | a fluorogenic substrate | Pteropus alecto | Pyr-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Pteropus alecto |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Pteropus alecto |
General Information | Comment | Organism |
---|---|---|
evolution | phylogenetic analysis and sequence comparisons. Differences may exist between furin proteases present in fruit bats compared to furins in other mammalian species, and these differences may impact protease usage for viral glycoprotein processing. Subtle differences in cellular distribution and localization of furin or trafficking through trans-Golgi network may exist between different mammalian species | Pteropus alecto |
physiological function | fruit bat cells have homologues of cathepsin and furin proteases capable of cleaving and activating both the cathepsin-dependent Hendra virus F and the furin-dependent parainfluenza virus 5 F proteins, involvement of a furin protease in the cleavage of the PIV5 fusion protein, overview | Pteropus alecto |