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Literature summary for 3.4.21.75 extracted from

  • El Najjar, F.; Lampe, L.; Baker, M.L.; Wang, L.F.; Dutch, R.E.
    Analysis of cathepsin and furin proteolytic enzymes involved in viral fusion protein activation in cells of the bat reservoir host (2015), PLoS ONE, 10, e0115736.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis Pteropus alecto

Inhibitors

Inhibitors Comment Organism Structure
decanoyl-Arg-Val-Lys-Arg-chloromethyl ketone
-
Pteropus alecto

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus furin is primarily located in the Golgi and trans-Golgi network, and it can also circulate between the cell surface and the trans-Golgi network Pteropus alecto 5794
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trans-Golgi network
-
Pteropus alecto 5802
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Pteropus alecto

Organism

Organism UniProt Comment Textmining
Pteropus alecto
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Pyr-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin + H2O a fluorogenic substrate Pteropus alecto Pyr-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Pteropus alecto

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Pteropus alecto

General Information

General Information Comment Organism
evolution phylogenetic analysis and sequence comparisons. Differences may exist between furin proteases present in fruit bats compared to furins in other mammalian species, and these differences may impact protease usage for viral glycoprotein processing. Subtle differences in cellular distribution and localization of furin or trafficking through trans-Golgi network may exist between different mammalian species Pteropus alecto
physiological function fruit bat cells have homologues of cathepsin and furin proteases capable of cleaving and activating both the cathepsin-dependent Hendra virus F and the furin-dependent parainfluenza virus 5 F proteins, involvement of a furin protease in the cleavage of the PIV5 fusion protein, overview Pteropus alecto