Any feedback?
Literature summary for 3.4.21.75 extracted from
- Furin mediates brain-derived neurotrophic factor upregulation in cultured rat astrocytes exposed to oxygen-glucose deprivation (2015), J. Neurosci. Res., 93, 189-194.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-brain-derived neurotrophic factor + H2O | Rattus norvegicus | - |
mature brain-derived neurotrophic factor + ? | - |
? |  |
| pro-brain-derived neurotrophic factor + H2O | Rattus norvegicus Sprague Dawley | - |
mature brain-derived neurotrophic factor + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
| Rattus norvegicus Sprague Dawley | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | primary cortical | Rattus norvegicus | - |
| brain | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-brain-derived neurotrophic factor + H2O | - |
Rattus norvegicus | mature brain-derived neurotrophic factor + ? | - |
? | |
| pro-brain-derived neurotrophic factor + H2O | - |
Rattus norvegicus Sprague Dawley | mature brain-derived neurotrophic factor + ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Rattus norvegicus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | the enzyme is upregulated and cleaves certain substrates during hypoxia in cancer cells. In oxygen-glucose deprivation, expression of the enzyme and of brain-derived neurotrophic factor is upregulated | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | furin inhibition reduces brain-derived neurotrophic factor maturation and secretion | Rattus norvegicus |
| physiological function | furin is upregulated and cleaves certain substrates during hypoxia in cancer cells, the enzyme mediates brain-derived neurotrophic factor upregulation in cultured rat astrocytes exposed to oxygen-glucose deprivation. Maturation of brain-derived neurotrophic factor in astrocytes requires furin-mediated endoproteolytic processing of the precursor protein pro-brain-derived neurotrophic factor to brain-derived neurotrophic factor | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
