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Literature summary for 3.4.21.75 extracted from

  • Essalmani, R.; Susan-Resiga, D.; Chamberland, A.; Abifadel, M.; Creemers, J.W.; Boileau, C.; Seidah, N.G.; Prat, A.
    In vivo evidence that furin from hepatocytes inactivates PCSK9 (2011), J. Biol. Chem., 286, 4257-4263.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.75

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
proprotein convertase PCSK9 + H2O Mus musculus
-
 ? PCSK9 is inactivated by furin by cleavage at residue R218. PCSK9 mutants R218S and F216L show a 50% reduction in the levels of the inactivated form ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
proprotein convertase PCSK9 + H2O
-
 Mus musculus ? PCSK9 is inactivated by furin by cleavage at residue R218. PCSK9 mutants R218S and F216L show a 50% reduction in the levels of the inactivated form ?
proprotein convertase PCSK9 + H2O
-
 Mus musculus ? PCSK9 is inactivated by furin by cleavage at residue R218 ?

General Information

General Information Comment Organism
physiological function in mice lacking furin in hepatocytes, the PCSK9-inactivated form is strongly reduced. Full-length, membrane-bound, but not soluble, furin is the cognate convertase which inactivates PCSK9 by cleavage at R218 Mus musculus