Literature summary for 3.4.21.75 extracted from

Tong, Y.; Tong, S.; Zhao, X.; Wang, J.; Jun, J.; Park, J.; Wands, J.; Li, J.
Initiation of duck hepatitis B virus infection requires cleavage by a furin-like protease (2010), J. Virol., 84, 4569-4578.

Search for more literature for 3.4.21.75

Inhibitors

Inhibitors	Comment	Organism	Structure
decanoyl-RVKR-chloromethylketone	the furin inhibitor reduces DHBV infection of primary duck hepatocytes	Anas platyrhynchos

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endosome	-	Anas platyrhynchos	5768	-

Organism

Organism	UniProt	Comment	Textmining
Anas platyrhynchos	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	-	Anas platyrhynchos	-
liver	-	Anas platyrhynchos	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
duck carboxypeptidase D + H2O	i.e. DCPD, duck carboxypeptidase D acts as species-specific docking receptor for the duck hepatitis B virus. No cleavage of recombinant DCPD expressed in LMH cells	Anas platyrhynchos	?	-	?
duck hepatitis B virus large envelope pre-S protein + H2O	the protein needs to be cleaved by duck endosomal furin or furin-like proprotein convertase for duck hepatocyte infection by duck hepatitis B virus	Anas platyrhynchos	?	-	?

Synonyms

Synonyms	Comment	Organism
furin-like proprotein convertase	-	Anas platyrhynchos
furin-like protease	-	Anas platyrhynchos

General Information

General Information	Comment	Organism
malfunction	furin or a furin-like proprotein convertase facilitates duck hepatitis B virus, DHBV, infection by cleaving both the docking receptor and the viral large envelope protein	Anas platyrhynchos

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Release 2023.1 (January 2023)