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Literature summary for 3.4.21.75 extracted from
- Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors (2010), Int. J. Biol. Sci., 6, 89-95.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| decanoyl-RVKR-chloromethyl ketone | - |
Mus musculus |  |
| additional information | design of specific small molecule inhibitors targeting furi, overview | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | 3D structural environment of the furin binding pocket surrounding the core region P6-P2' of furin substrates, comparison to other protein convertases, to allow the rational design of novel specific molecular inhibitors targeting specific members of the mammalian proprotein convertase family, overview. The furin autocleavage site is RGVTKR75 -/- | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | furin belongs to the subtilisin/Kex2p-like proprotein convertases | Mus musculus |
| Proprotein convertase | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | molecular evolution of enzyme function in the proprotein convertase family, overview | Mus musculus |
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Release 2023.1 (January 2023)
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