Literature summary for 3.4.21.75 extracted from

Semenov, A.G.; Postnikov, A.B.; Tamm, N.N.; Seferian, K.R.; Karpova, N.S.; Bloshchitsyna, M.N.; Koshkina, E.V.; Krasnoselsky, M.I.; Serebryanaya, D.V.; Katrukha, A.G.
Processing of pro-brain natriuretic peptide is suppressed by O-glycosylation in the region close to the cleavage site (2009), Clin. Chem., 55, 489-498.

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Protein Variants

Protein Variants	Comment	Organism
additional information	furin-deficient LoVo cells are uncapable to process pro-B-type natriuretic peptide, coexpression of human wild-type furin compensates and results in effective pro-B-type natriuretic peptide cleavage. Suppression of furin in HEK-293 cells by siRNA leads to the same result, overview	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
decanoyl-RVKR-chloromethyl ketone	inhibition of furin inhibits processing of pro-B-type natriuretic peptide	Homo sapiens
additional information	O-glycosylation of substrate proBNP in the cleavage site region at Thr71 reduces furin cleaving activity, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
pro-B-type natriuretic peptide + H2O	Homo sapiens	activation by N-terminal fragment cleavage of proBNP in human plasma through furin	B-type natriuretic peptide + pro-peptide of B-type natriuretic peptide	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pro-B-type natriuretic peptide + H2O	activation by N-terminal fragment cleavage of proBNP in human plasma through furin	Homo sapiens	B-type natriuretic peptide + pro-peptide of B-type natriuretic peptide	-	?
pro-B-type natriuretic peptide + H2O	cleavage sequence is Arg73-Ala-Pro-Arg76-/-Ser77	Homo sapiens	B-type natriuretic peptide + pro-peptide of B-type natriuretic peptide	-	?

General Information

General Information	Comment	Organism
malfunction	inhibition of furin inhibits processing of pro-B-type natriuretic peptide	Homo sapiens

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Release 2023.1 (January 2023)