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Literature summary for 3.4.21.75 extracted from

  • Ikonomov, O.C.; Fligger, J.; Sbrissa, D.; Dondapati, R.; Mlak, K.; Deeb, R.; Shisheva, A.
    Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin (2009), J. Biol. Chem., 284, 3750-3761.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
CHO cell lines stably expressing Tac-furin chimeric protein (extracellular/transmembrane domain of the interleukin-2 receptor alpha-chain (Tac) and the cytoplasmic domain of furin) Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information siRNA-mediated depletion of endogenous c-Jun NH2-terminal kinase-interacting leucine zipper protein (JLP) or phosphoinositide kinase for position 5 containing a five finger domain (PIKfyve), profoundly delays microtubule-based transport of chimeric furin (Tac-furin) from endosomes to the trans-Golgi network in a CHO cell line, which is rescued upon ectopic expression of siRNA-resistant JLP or PIKfyve constructs Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-