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Literature summary for 3.4.21.75 extracted from

  • Ozden, S.; Lucas-Hourani, M.; Ceccaldi, P.E.; Basak, A.; Valentine, M.; Benjannet, S.; Hamelin, J.; Jacob, Y.; Mamchaoui, K.; Mouly, V.; Despres, P.; Gessain, A.; Butler-Browne, G.; Chretien, M.; Tangy, F.; Vidalain, P.O.; Seidah, N.G.
    Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein (2008), J. Biol. Chem., 283, 21899-21908.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
membrane-bound or soluble furin transiently expressed in HEK-293 cells synthetic construct

Inhibitors

Inhibitors Comment Organism Structure
Chloroquine weakly affects proprotein convertase activity and E3E2 processing. Additive inhibitory effect of chloroquine and decanoyl-RVKR-chloromethyl ketone on viral infection synthetic construct
decanoyl-RVKR-chloromethyl ketone furin inhibitor, inhibits E3E2 cleavage. Additive inhibitory effect of chloroquine and decanoyl-RVKR-chloromethyl ketone on viral infection synthetic construct

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000036
-
 viral precursor protein E3E2 R64A mutant peptide of E3E2 from Asian Chikungunya virus strain synthetic construct
0.000122
-
 viral precursor protein E3E2 wild-type E3E2 from Asian Chikungunya virus strain synthetic construct

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 synthetic construct 16020
-
soluble
-
 synthetic construct
-
-

Organism

Organism UniProt Comment Textmining
synthetic construct
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
viral precursor protein E3E2 processes E3E2 from African Chikungunya virus strain at the HRQRR642ST site, whereas a Chikungunya virus strain of Asian origin is cleaved at site RRQRR642SI synthetic construct ?
-
 ?

Synonyms

Synonyms Comment Organism
Proprotein convertase
-
 synthetic construct