Literature summary for 3.4.21.75 extracted from

Walker, M.B.; Miller, C.T.; Coffin Talbot, J.; Stock, D.W.; Kimmel, C.B.
Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning (2006), Dev. Biol., 295, 194-205.

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Application

Application	Comment	Organism
additional information	furin A activates endothelin 1 signaling	Danio rerio
additional information	furin B activates endothelin 1 signaling	Danio rerio

Protein Variants

Protein Variants	Comment	Organism
additional information	loss of furin A function causes only a partial loss of endothelin 1 function. Furin A mutants typically have wild-type looking anterior arch ventral cartilages that are abnormally fused to dorsal cartilages. Cartilages of the posterior arches are also typically wild type, with a low penetrance of cartilage reduction observed in the third and fourth arches. Shape changes and bony fusions between the opercle and posterior branchiostegal ray, and altered muscle insertion points near joint domains. Arches fail to correctly undergo ventral elongation before skeletogenesis begins. Furin A mutants have defects in intermediate domain elements of the pharyngeal skeleton and mildly ruffled fins. Expression of endothelin 1-dependent genes is downregulated. Later in development, expression of most of these genes recovers to near wild-type levels	Danio rerio

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	Q1KHF8	-	-
Danio rerio	Q1KHF9	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
embryo	-	Danio rerio	-

Synonyms

Synonyms	Comment	Organism
furin A	-	Danio rerio
furin B	-	Danio rerio

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Release 2023.1 (January 2023)