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Literature summary for 3.4.21.75 extracted from

  • Pesu, M.; Muul, L.; Kanno, Y.; OShea, J.J.
    Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma (2006), Blood, 108, 983-985.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.75

Activating Compound

Activating Compound Comment Organism Structure
additional information furin induced by interleukin 12 Mus musculus
additional information furin induced by interleukin 12 Homo sapiens

Application

Application Comment Organism
medicine interleukin 12 induction of furin plays a role in interferon gamma protein regulation and control of T helper 1 cell differentiation Mus musculus
medicine interleukin 12 induction of furin plays a role in interferon gamma protein regulation and control of T helper 1 cell differentiation Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
LoVo cells transfected with vector pSVLFur encoding furin Homo sapiens

Protein Variants

Protein Variants Comment Organism
D153A inactive furin mutant, fails to up-regulate interferon gamma protein Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha1-antitrypsin
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
additional information furin mRNA and protein highly expressed in T helper 1 cells compared with T helper 2 cells. Stat4 binding sites in the putative promoter region (2000 bp upstream of exon 1). Also present in CD4+ T cells Mus musculus
-
additional information preferentially expressed in T helper 1 cells in a Stat4-dependent manner Homo sapiens
-

Synonyms

Synonyms Comment Organism
Proprotein convertase
-
 Mus musculus
Proprotein convertase
-
 Homo sapiens