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Literature summary for 3.4.21.75 extracted from

  • Guimont, P.; Grondin, F.; Dubois, C.M.
    Sox9-dependent transcriptional regulation of the proprotein convertase furin (2007), Am. J. Physiol. Cell Physiol., 293, C172-C183.
    View publication on PubMed
Search for more literature for 3.4.21.75

Activating Compound

Activating Compound Comment Organism Structure
additional information L-Sox5 and Sox-6 act as negative regulators of Sox9-induced furin expression Homo sapiens
additional information relationship between Sox-9 dependent expression of furin and the maturation/bioactivation of substrates involved in chondrogenesis. Peak expression of both furin mRNA and furin parathyroid hormone-related peptide maturation in ATDC5 cells during chondrocyte nodule formation stage Mus musculus

Application

Application Comment Organism
additional information Sox-9 regulates furin during chondrogenesis Mus musculus
additional information Sox-9 regulates furin during chondrogenesis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
HepG2 cells transiently transfected with furin luciferase reporter constructs pGL2-P1, pGL2-P1A and pGL2-P1B Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information point mutations of sites A, B and C of furin P1A promoter. Mutations of site A and more importantly site B decreases Sox9-induced promoter activity, while mutations of both A and B sites result in only slight but nonsignificant additional inhibition. Mutation of site C does not reduce Sox9 activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
decanoyl-Arg-Val-Lys-Arg-chloromethylketone blocks furin activity, 99% inhibition of parathyroid hormone-related peptide maturation Mus musculus
hexa-D-arginine blocks furin activity, 85% inhibition of parathyroid hormone-related peptide maturation Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information ATDC5 cell Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
parathyroid hormone-related peptide + H2O
-
 Mus musculus ?
-
 ?
TACE/ADAM17 + H2O
-
 Mus musculus ?
-
 ?
TGFbeta1 + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
Proprotein convertase
-
 Mus musculus
Proprotein convertase
-
 Homo sapiens