Literature summary for 3.4.21.75 extracted from

Basak, A.; Koch, P.; Dupelle, M.; Fricker, L.D.; Devi, L.A.; Chretien, M.; Seidah, N.G.
Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1 (2001), J. Biol. Chem., 276, 32720-32728.

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Inhibitors

Inhibitors	Comment	Organism	Structure
PenLen (rSAAS-(221-2546))	neuroendocrine protein proSAAS-derived peptide	Homo sapiens
SAAS-(235-244)	neuroendocrine protein proSAAS-derived peptide	Homo sapiens
SAAS-(235-246)	neuroendocrine protein proSAAS-derived peptide	Homo sapiens
SAAS-(235-246)P1'A	neuroendocrine protein proSAAS-derived peptide	Homo sapiens
SAAS-(235-246)P2'A	neuroendocrine protein proSAAS-derived peptide	Homo sapiens
SAAS-(235-246)P3A	neuroendocrine protein proSAAS-derived peptide	Homo sapiens
SAAS-(235-246)P3AP5A	neuroendocrine protein proSAAS-derived peptide	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	human	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000261	-	SAAS-(235-244)	pH 7.4, 37°C	Homo sapiens
0.00128	-	SAAS-(235-246)P1'A	pH 7.4, 37°	Homo sapiens
0.0044	-	SAAS-(235-246)P2'A	pH 7.4, 37°C	Homo sapiens
0.0193	-	PenLen (rSAAS-(221-246))	pH 7.4, 37°C	Homo sapiens
0.0394	-	SAAS-(235-246)	pH 7.4, 37°C	Homo sapiens
0.092	-	SAAS-(235-246)P3A	pH 7.4, 37°C	Homo sapiens

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Release 2023.1 (January 2023)