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Literature summary for 3.4.21.75 extracted from

  • Cameron, A.; Appel, J.; Houghten, R.A.; Lindberg, I.
    Polyarginines are potent furin inhibitors (2000), J. Biol. Chem., 275, 36741-36749.
    View publication on PubMed
Search for more literature for 3.4.21.75

Application

Application Comment Organism
medicine potential therapeutic value of furin inhibitors, alpha1-PDX is able to block in vivo maturation of pro-gB, the cytomegalovirus envelope glycoprotein Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
cDNA cloning Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
Ac-D-Trp-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2
-
 Mus musculus
Ac-D-Trp-D-Arg-D-Arg-D-Arg-D-Arg-D-Leu-NH2
-
 Mus musculus
Ac-D-Trp-D-Arg-D-Arg-D-Arg-D-Ile-D-Arg-NH2
-
 Mus musculus
Ac-D-Trp-D-Arg-D-Arg-D-Arg-D-Ile-D-Leu-NH2
-
 Mus musculus
Ac-HHKRRR-NH2
-
 Mus musculus
Ac-HRKRRR-NH2
-
 Mus musculus
Ac-KHKRRR-NH2
-
 Mus musculus
Ac-KRKRRR-NH2
-
 Mus musculus
Ac-LLRVKR
-
 Mus musculus
Ac-LLRVKR-NH2
-
 Mus musculus
Ac-MHKRRR-NH2
-
 Mus musculus
Ac-MRKRRR-NH2
-
 Mus musculus
Ac-RHKRRR-NH2
-
 Mus musculus
Ac-RRKRRR-NH2
-
 Mus musculus
alpha1-PDX
-
 Homo sapiens
hepta-L-arginine
-
 Mus musculus
hexa-D-arginine
-
 Mus musculus
hexa-L-arginine
-
 Mus musculus
LLRVKR
-
 Mus musculus
LLRVKR-NH2
-
 Mus musculus
nona-L-arginine most potent inhibitor Mus musculus
octa-L-arginine
-
 Mus musculus
penta-L-arginine
-
 Mus musculus
tetra-L-arginine
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus trans Golgi network Mus musculus 5794
-
Golgi apparatus trans Golgi network Homo sapiens 5794
-
membrane membrane-bound Mus musculus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
59000
-
 gel filtration Mus musculus
61000
-
 Western blotting with anti-furin antiserum MON148 Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-
Mus musculus
-
 mouse
-

Purification (Commentary)

Purification (Comment) Organism
recombinant furin Mus musculus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.35
-
 recombinant furin Mus musculus

Storage Stability

Storage Stability Organism
-80°C, 10% glycerol, no detectable loss of activity over 6 months Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00004
-
 nona-L-arginine pH 7.0, 37°C Mus musculus
0.000042
-
 nona-L-arginine pH 7.0, 37°C Mus musculus
0.000061
-
 octa-L-arginine pH 7.0, 37°C Mus musculus
0.000068
-
 hepta-L-arginine pH 7.0, 37°C Mus musculus
0.000106
-
 hexa-D-arginine pH 7.0, 37°C Mus musculus
0.000114
-
 tetra-L-arginine pH 7.0, 37°C Mus musculus
0.00042
-
 LLRVKR pH 7.0, 37°C Mus musculus
0.0008
-
 LLRVKR-NH2 pH 7.0, 37°C Mus musculus
0.00099
-
 penta-L-arginine pH 7.0, 37°C Mus musculus
0.0013
-
 Ac-RRKRRR-NH2 pH 7.0, 37°C Mus musculus
0.0016
-
 Ac-KRKRRR-NH2 pH 7.0, 37°C Mus musculus
0.0021
-
 Ac-HRKRRR-NH2 pH 7.0, 37°C Mus musculus
0.0023
-
 Ac-MRKRRR-NH2 pH 7.0, 37°C Mus musculus
0.0024
-
 Ac-D-Trp-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2 pH 7.0, 37°C Mus musculus
0.0034
-
 LLRVKR-NH2 pH 7.0, 37°C Mus musculus
0.0034
-
 Ac-RHKRRR-NH2 pH 7.0, 37°C Mus musculus
0.0035
-
 AcLLRVKR pH 7.0, 37°C Mus musculus
0.0052
-
 Ac-KHKRRR-NH2 pH 7.0, 37°C Mus musculus
0.0053
-
 Ac-D-Trp-D-Arg-D-Arg-D-Arg-D-Arg-D-Leu-NH2 pH 7.0, 37°C Mus musculus
0.0064
-
 tetra-L-arginine pH 7.0, 37°C Mus musculus
0.007
-
 Ac-D-Trp-D-Arg-D-Arg-D-Arg-D-Ile-D-Arg-NH2 pH 7.0, 37°C Mus musculus
0.0103
-
 Ac-HHKRRR-NH2 pH 7.0, 37°C Mus musculus
0.0132
-
 Ac-MHKRRR-NH2 pH 7.0, 37°C Mus musculus
0.0227
-
 Ac-D-Trp-D-Arg-D-Arg-D-Arg-D-Ile-D-Leu-NH2 pH 7.0, 37°C Mus musculus