Literature summary for 3.4.21.73 extracted from

Meznarich, J.; Malchodi, L.; Helterline, D.; Ramsey, S.A.; Bertko, K.; Plummer, T.; Plawman, A.; Gold, E.; Stempien-Otero, A.
Urokinase plasminogen activator induces pro-fibrotic/m2 phenotype in murine cardiac macrophages (2013), PLoS ONE, 8, e57837.

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Cloned(Commentary)

Cloned (Comment)	Organism
overexpression of urokinase plasminogen activator in macrophages, elevation of the pro-inflammatory cytokine interleukin-6 in hearts of transgenic mice, interleukin-6 is not a major effector of the enzyme-induced cardiac fibrosis, transcriptome analysis, overview	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
uPA	-	Mus musculus
Urokinase plasminogen activator	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	overexpression of urokinase plasminogen activator in macrophages induces spontaneous macrophage accumulation and fibrosis specific to the heart in mice	Mus musculus
physiological function	urokinase plasminogen activator induces pro-fibrotic/m2 phenotype in murine cardiac macrophages, overview. The phenotype is adopted after migration of the macrophages to the heart. Elevation of the pro-inflammatory cytokine interleukin-6 in hearts of transgenic mice overexpressing the enzyme, interleukin-6 is not a major effector of the enzyme-induced cardiac fibrosis	Mus musculus

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Release 2023.1 (January 2023)