Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00749 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MiaPaCa-2 cell | - |
Homo sapiens | - |
PANC-1 cell | - |
Homo sapiens | - |
serum | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
uPA | - |
Homo sapiens |
Urokinase plasminogen activator | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | suppression of uPA retards development of pancreatic cancer in nude mice and increases sensitization to gemcitabine | Homo sapiens |
metabolism | a poor prognosis of pancreatic ductal adenocarcinoma is correlated with increased expression of urokinase plasminogen activator | Homo sapiens |
physiological function | role of the enzyme in pancreatic ductal adenocarcinoma cancer stem cells, a large fraction of these side population cells are CD44 and CD24 positive, are gemcitabine resistant, possess sphere-forming ability, and exhibit increased tumorigenicity. The enzyme interacts directly with transcription factors LIM homeobox-2 (Lhx2), homeobox transcription factor A5 (HOXA5), and Hey to possibly promote cancer stemness. The enzyme regulates Lhx2 expression by suppressing expression of miR-124 and p53 expression by repressing its promoter by inactivating HOXA5. Regulation of gene transcription by the enzyme contributes to cancer stemness and clinical lethality | Homo sapiens |