Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | uPA is produced and secreted as an inactive single-chain polypeptide, termed pro-uPA, which lacks plasminogen-activating activity. The binding of pro-uPA to urokinase receptor uPAR induces its activation which in turn converts plasminogen to the active serine protease plasmin | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | recombinant, active | Homo sapiens | - |
osteosarcoma cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
uPA | - |
Homo sapiens |
Urokinase plasminogen activator | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | downregulation of uPA and uPAR by early growth response 1, EGR1, forced expression of EGR1 decreases the expression of uPA and urokinase receptor uPAR proteins. uPA activity is decreased 0.49fold by EGR1 in Saos-2 cells | down |
General Information | Comment | Organism |
---|---|---|
additional information | chemotherapy prevents osteosarcoma cell invasion by down-regulation of urokinase plasminogen activity via up-regulation of transcription factor early growth response 1, EGR1, during chemotherapy period, overview | Homo sapiens |