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Literature summary for 3.4.21.73 extracted from

  • Matsunoshita, Y.; Ijiri, K.; Ishidou, Y.; Nagano, S.; Yamamoto, T.; Nagao, H.; Komiya, S.; Setoguchi, T.
    Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1 (2011), PLoS ONE, 6, e16234.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification uPA is produced and secreted as an inactive single-chain polypeptide, termed pro-uPA, which lacks plasminogen-activating activity. The binding of pro-uPA to urokinase receptor uPAR induces its activation which in turn converts plasminogen to the active serine protease plasmin Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant, active Homo sapiens
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osteosarcoma cell
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Homo sapiens
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Synonyms

Synonyms Comment Organism
uPA
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Homo sapiens
Urokinase plasminogen activator
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens downregulation of uPA and uPAR by early growth response 1, EGR1, forced expression of EGR1 decreases the expression of uPA and urokinase receptor uPAR proteins. uPA activity is decreased 0.49fold by EGR1 in Saos-2 cells down

General Information

General Information Comment Organism
additional information chemotherapy prevents osteosarcoma cell invasion by down-regulation of urokinase plasminogen activity via up-regulation of transcription factor early growth response 1, EGR1, during chemotherapy period, overview Homo sapiens