Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.73 extracted from

  • Venkatraman, L.; Li, H.; Dewey Jr., C.; White, J.; Bhowmick, S.; Yu, H.; Tucker-Kellogg, L.
    Steady states and dynamics of urokinase-mediated plasmin activation in silico and in vitro (2011), Biophys. J., 101, 1825-1834.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.73

Activating Compound

Activating Compound Comment Organism Structure
additional information plasmin and urokinase-type plasminogen activator can activate each other through proteolytic cleavage Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secreted in inactive form Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification secretion in inactive forms, and activation by plasmin through proteolytic cleavage, mathematical modeling, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?

Synonyms

Synonyms Comment Organism
uPA
-
 Homo sapiens
Urokinase
-
 Homo sapiens
Urokinase-type plasminogen activator
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function plasmin and urokinase-type plasminogen activator are ubiquitous proteases that regulate the extracellular environment and activate each other through proteolytic cleavage. Although neither plasmin nor urokinase-type plasminogen activator exhibit allosteric cooperativity, modeling shows that cooperativity occurs at the system level because of substrate competition, computational simulations and bifurcation analysis, overview. Ultrasensitive, bistable activation of UPA-PLS is possible in the presence of substrate competition Homo sapiens