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Literature summary for 3.4.21.73 extracted from

  • Odaka, T.; Kobayashi, K.; Takahashi, K.; Nakamura, H.; Matsuoka, T.
    Effect of prostaglandin E2 on urokinase-type plasminogen activator production by human lung fibroblasts (2009), Scand. J. Clin. Lab. Invest., 69, 225-233.
    View publication on PubMed
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Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-
extracellular uPA secretion from human lung fibroblasts Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast lung Homo sapiens
-
lung
-
 Homo sapiens
-
lung fibroblast cell line lung fibroblast cell line Homo sapiens
-
WI-38 cell lung fibroblast cell line Homo sapiens
-

Synonyms

Synonyms Comment Organism
uPA
-
 Homo sapiens
Urokinase-type plasminogen activator
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of uPA mRNA and enzyme production is increased by the addition of prostaglandin E2, PGE2, in cell lines of lung fibroblasts, although the cell surface uPA level is comparable to that of PGE2 untreated cells, overview up

General Information

General Information Comment Organism
malfunction uPA is an important protease believed responsible for several tumour characteristics through its activation of certain proteases and growth factors. uPA is essential in the degradation of peritumour extracellular matrix. uPA, induced by PGE2 from stromal fibroblasts surrounding lung tumour, thus appears to play an important role through EP receptors Homo sapiens