Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | uPA needs to be activated proteolytically. Sphingosine 1-phosphate receptor S1P1 overexpression in U-118 MG cells results in potent stimulation of uPA activity regardless of S1P treatment, expression of receptors S1P2 and S1P3 does not affect uPA activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | uPA is secreted from glioblastoma cells as inactive pro-uPA and is converted to an active form at the cell surface where it binds to its receptor uPAR | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | Homo sapiens | uPA needs to be activated | plasmin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioblastoma cell | - |
Homo sapiens | - |
U-118 MG cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | - |
Homo sapiens | plasmin + ? | - |
? | |
plasminogen + H2O | uPA needs to be activated | Homo sapiens | plasmin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
uPA | - |
Homo sapiens |
Urokinase plasminogen activator | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | inhibition of sphingosine kinase blocks basal expression of uPA and uPAR, as well as glioma cell invasion, however overexpression of sphingosine kinase does not augment sphingosine-1-phosphate receptor-mediated enhancement of uPA activity or invasion | down |
Homo sapiens | sphingosine-1-phosphate, S1P, induces expression of uPA and of its receptor uPAr in gliobalstoma multiforme cells. S1P1 receptor overexpression leads to the most dramatic induction of the uPA system and of spheroid invasion, even in the absence of added S1P, while expression of receptors S1P2 and S1P3 does not affect uPA expression, overview | up |
General Information | Comment | Organism |
---|---|---|
malfunction | uPA stimulates glioblastoma multiforme cell invasiveness, in sphingosine-1-phosphate-induced invasion using a spheroid invasion assay | Homo sapiens |
additional information | sphingosine kinase is necessary for basal activity of the uPA system and glioma cell invasion, while sphingosine 1-phosphate receptor signaling enhances invasion, partially through uPA and CCN1 | Homo sapiens |