Literature summary for 3.4.21.73 extracted from

Humphries, J.; Gossage, J.A.; Modarai, B.; Burnand, K.G.; Sisson, T.H.; Murdoch, C.; Smith, A.
Monocyte urokinase-type plasminogen activator up-regulation reduces thrombus size in a model of venous thrombosis (2009), J. Vasc. Surg., 50, 1127-1134.

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Application

Application	Comment	Organism
medicine	macrophages, recruited into venous thrombi, can be used to target uPA gene constructs to the thrombus after systemic administration	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	transduction of blood monocyte-derived macrophages with uPA-containing adenovirus leads to uPA overexpression. Uptake of the cells into an induced thrombus in mouse leads to increased migration rate of the macrophages and MM6 cells in the thombus, overview. Systemic administration of uPA up-regulated human blood monocyte-derived macrophages reduces thrombus size in an experimental model of venous thrombosis. Adenovirus-uPA transduction increases blood monocyte-derived macrophages fibrinolytic activity by 150fold, and uPAR and PAI-1 production by 1.6fold, it also induces cytokine expression, overview	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	blood monocyte-derived	Homo sapiens	-
monocyte	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
uPA	-	Homo sapiens
urokinase-type plasminogen	-	Homo sapiens

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Release 2023.1 (January 2023)