Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.73 extracted from

  • Cunningham, O.; Campion, S.; Perry, V.H.; Murray, C.; Sidenius, N.; Docagne, F.; Cunningham, C.
    Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation (2009), Glia, 57, 1802-1814.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information uPA transcription and activity is only markedly increased during chronic neurodegeneration, not during acute intracerebral lipopolysaccharide-induced or acute kainate-induced neurodegeneration. Increase in total plasminogen activation with progression of prion disease is apparent in both soluble and membrane fractions Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
quantitative uPA expression analysis Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
plasminogen activator inhibitor 1 i.e. PAI-1 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Mus musculus
-
plasmin + ?
-
?
plasminogen + H2O Mus musculus C57BL/6
-
plasmin + ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
C57BL/6 mice
-
Mus musculus C57BL/6
-
C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain from ME7-infected mice Mus musculus
-
microglia
-
Mus musculus
-
additional information the uPA receptor, a GPI-linked cell surface protein, occurs in macrophages infiltrating the central nervous system, and in the cerebrospinal fluid during a number of CNS pathologies Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
Mus musculus plasmin + ?
-
?
plasminogen + H2O
-
Mus musculus C57BL/6 plasmin + ?
-
?

Synonyms

Synonyms Comment Organism
uPA
-
Mus musculus
Urokinase plasminogen activator
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
assay at Mus musculus

Expression

Organism Comment Expression
Mus musculus uPA transcription and activity is only markedly increased during chronic neurodegeneration, not during acute intracerebral lipopolysaccharide-induced or acute kainate-induced neurodegeneration. Increase in total plasminogen activation with progression of prion disease is apparent in both soluble and membrane fractions up

General Information

General Information Comment Organism
malfunction uPA transcription and activity is only markedly increased during chronic neurodegeneration, not during acute intracerebral lipopolysaccharide-induced or acute kainate-induced neurodegeneration. Increase in total plasminogen activation with progression of prion disease is apparent in both soluble and membrane fractions Mus musculus
metabolism involvement of the uPAR/uPA system in CNS function and pathology, overview Mus musculus