Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | increase of uPA activity and expression by freezing/thawing process in porcine uterus endometrial epithelium cells | Sus scrofa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the MAP kinase inhibitors SP600125, a JNK inhibitor, and SB203580, a p38 inhibitor, do not inhibit uPA in frozen-thawed porcine uterus endometrial epithelium cells | Sus scrofa | |
PAI-1 | - |
Sus scrofa | |
PD98059 | the ERK MAP kinase inhibitor dramatically reduces the uPA expression in the frozen-thawed porcine uterus endometrial epithelium cells | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | Sus scrofa | - |
plasmin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endometrium | primary | Sus scrofa | - |
epithelial cell | primary | Sus scrofa | - |
uterine endometrium | - |
Sus scrofa | - |
uterus | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | - |
Sus scrofa | plasmin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
uPA | - |
Sus scrofa |
urokinase-type PA | - |
Sus scrofa |
Organism | Comment | Expression |
---|---|---|
Sus scrofa | in human endometrial cells, uPA and PAI-1 expression is regulated by steroid hormones such as estradiol, and progesterone. P4 suppresses uPA in epithelial cells and enhances inhibitor PAI-1 expression in both epithelial and stromal cells | down |
Sus scrofa | increase of uPA activity and expression by freezing/thawing process in porcine uterus endometrial epithelium cells. Reactive oxygen species, that occur in high rates in response to the freezing-thawing stimulus, actively participate in the induction of uPA expression in frozen-thawed and in vitro-cultured cells | up |
General Information | Comment | Organism |
---|---|---|
additional information | plasminogen activators are serine proteases that are classified as either urokinase-type PA, uPA, or tissue-type PA, tPA, based on their molecular mass | Sus scrofa |