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Literature summary for 3.4.21.73 extracted from

  • Kim, T.S.; Kwon, E.H.; Kim, S.U.; Choi, H.S.; Lim, H.J.; Park, S.B.; Park, S.J.; Koo, D.B.; Park, C.K.; Lee, D.S.
    Activation and expression of urokinase-type plasminogen activator are modulated by freezing/thawing process through activation of redox signal pathway in primary porcine endometrial cells (2010), Cryobiology, 60, 211-216.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information increase of uPA activity and expression by freezing/thawing process in porcine uterus endometrial epithelium cells Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
additional information the MAP kinase inhibitors SP600125, a JNK inhibitor, and SB203580, a p38 inhibitor, do not inhibit uPA in frozen-thawed porcine uterus endometrial epithelium cells Sus scrofa
PAI-1
-
Sus scrofa
PD98059 the ERK MAP kinase inhibitor dramatically reduces the uPA expression in the frozen-thawed porcine uterus endometrial epithelium cells Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Sus scrofa
-
plasmin + ?
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endometrium primary Sus scrofa
-
epithelial cell primary Sus scrofa
-
uterine endometrium
-
Sus scrofa
-
uterus
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
Sus scrofa plasmin + ?
-
?

Synonyms

Synonyms Comment Organism
uPA
-
Sus scrofa
urokinase-type PA
-
Sus scrofa

Expression

Organism Comment Expression
Sus scrofa in human endometrial cells, uPA and PAI-1 expression is regulated by steroid hormones such as estradiol, and progesterone. P4 suppresses uPA in epithelial cells and enhances inhibitor PAI-1 expression in both epithelial and stromal cells down
Sus scrofa increase of uPA activity and expression by freezing/thawing process in porcine uterus endometrial epithelium cells. Reactive oxygen species, that occur in high rates in response to the freezing-thawing stimulus, actively participate in the induction of uPA expression in frozen-thawed and in vitro-cultured cells up

General Information

General Information Comment Organism
additional information plasminogen activators are serine proteases that are classified as either urokinase-type PA, uPA, or tissue-type PA, tPA, based on their molecular mass Sus scrofa