Literature summary for 3.4.21.73 extracted from

Veljkovic, D.K.; Rivard, G.E.; Diamandis, M.; Blavignac, J.; Cramer-Borde, E.M.; Hayward, C.P.
Increased expression of urokinase plasminogen activator in Quebec platelet disorder is linked to megakaryocyte differentiation (2009), Blood, 113, 1535-1542.

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Application

Application	Comment	Organism
medicine	the overexpression of uPA in Quebec platelet disease emerges with megakaryocyte differentiation, without altering the expression of flanking genes. uPA is costored with-granule proteins prior to their proteolysis in Quebec platelet disease	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with Quebec platelet disease	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood platelet	uPA shows extensive colocalization with alpha-granule proteins in both cultured Quebec platelet disease megakaryocytes and platelets, and with plasminogen in Quebec platelet disease platelets	Homo sapiens	-
megakaryocyte	CD34+ progenitor cells express normal amounts of uPA, while their differentiation into megakaryocytes results in abnormally increased expression of the uPA gene but not the flanking genes for vinculin or calcium/calmodulin-dependent protein kinase IIgamma on chromosome 10. uPA shows extensive colocalization with alpha-granule proteins in both cultured Quebec platelet disease megakaryocytes and platelets, and with plasminogen in Quebec platelet disease platelets	Homo sapiens	-

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Release 2023.1 (January 2023)