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Literature summary for 3.4.21.73 extracted from

  • Stempien-Otero, A.; Plawman, A.; Meznarich, J.; Dyamenahalli, T.; Otsuka, G.; Dichek, D.A.
    Mechanisms of cardiac fibrosis induced by urokinase plasminogen activator (2006), J. Biol. Chem., 281, 15345-15351.
    View publication on PubMed
Search for more literature for 3.4.21.73

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Mus musculus
-
 plasmin + ?
-
 ?
plasminogen + H2O Homo sapiens hearts with end-stage failure and fibrosis have macrophage accumulation and elevated plasminogen activator activity, mechanisms that link macrophage accumulation and plasminogen activator activity with cardiac fibrosis, dependent on localization of uPA by the uPA receptor uPAR, on activation of plasminogen by uPA and subsequent activation of transforming growth factor-beta1 and matrix metalloproteinase MMP-2 and MMP-9 by plasmin, overview, uPA-induced cardiac fibrosis can be attenuated by treatment with verapamil, plasminogen is necessary for uPA-induced cardiac fibrosis and macrophage accumulation, but uPAR is not plasmin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Mus musculus
-
heart hearts with end-stage failure and fibrosis have macrophage accumulation and elevated plasminogen activator activity, mechanisms that link macrophage accumulation and plasminogen activator activity with cardiac fibrosis, overview Homo sapiens
-
macrophage
-
 Mus musculus
-
macrophage from bone-marrow Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
 Mus musculus plasmin + ?
-
 ?
plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?
plasminogen + H2O hearts with end-stage failure and fibrosis have macrophage accumulation and elevated plasminogen activator activity, mechanisms that link macrophage accumulation and plasminogen activator activity with cardiac fibrosis, dependent on localization of uPA by the uPA receptor uPAR, on activation of plasminogen by uPA and subsequent activation of transforming growth factor-beta1 and matrix metalloproteinase MMP-2 and MMP-9 by plasmin, overview, uPA-induced cardiac fibrosis can be attenuated by treatment with verapamil, plasminogen is necessary for uPA-induced cardiac fibrosis and macrophage accumulation, but uPAR is not Homo sapiens plasmin + ?
-
 ?

Synonyms

Synonyms Comment Organism
uPA
-
 Mus musculus
uPA
-
 Homo sapiens
Urokinase plasminogen activator
-
 Mus musculus
Urokinase plasminogen activator
-
 Homo sapiens