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Literature summary for 3.4.21.73 extracted from

  • Barber, C.G.; Dickinson, R.P.; Fish, P.V.
    Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-Isoquinolinylguanidines (2004), Bioorg. Med. Chem. Lett., 14, 3227-3230.
    View publication on PubMed
Search for more literature for 3.4.21.73

Inhibitors

Inhibitors Comment Organism Structure
2-(4-chloro-7-(2-cyano-6-methoxyphenyl)isoquinolin-1-yl)guanidine comparison of selectivity with t-plasminogen activator and plasmin Homo sapiens
2-(4-chloro-7-(2-methoxyphenyl)isoquinolin-1-yl)guanidine comparison of selectivity with t-plasminogen activator and plasmin Homo sapiens
2-(4-chloro-7-(3-methoxyphenyl)isoquinolin-1-yl)guanidine comparison of selectivity with t-plasminogen activator and plasmin Homo sapiens
2-(7-(1,3-benzodioxol-5-yl)-4-chloroisoquinolin-1-yl)guanidine comparison of selectivity with t-plasminogen activator and plasmin Homo sapiens
2-(7-(1,3-benzodioxol-5-yl)isoquinolin-1-yl)guanidine comparison of selectivity with t-plasminogen activator and plasmin Homo sapiens
2-(7-phenylisoquinolin-1-yl)guanidine comparison of selectivity with t-plasminogen activator and plasmin Homo sapiens
3-(4-chloro-1-((diaminomethylene)amino)isoquinolin-7-yl)-5-methoxybenzoic acid comparison of selectivity with t-plasminogen activator and plasmin Homo sapiens
3-(4-chloro-1-((diaminomethylene)amino)isoquinolin-7-yl)benzoic acid comparison of selectivity with t-plasminogen activator and plasmin Homo sapiens
4-(4-chloro-1-((diaminomethylene)amino)isoquinolin-7-yl)benzoic acid comparison of selectivity with t-plasminogen activator and plasmin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000009
-
 3-(4-chloro-1-((diaminomethylene)amino)isoquinolin-7-yl)-5-methoxybenzoic acid
-
 Homo sapiens
0.000037
-
 3-(4-chloro-1-((diaminomethylene)amino)isoquinolin-7-yl)benzoic acid
-
 Homo sapiens
0.000082
-
 4-(4-chloro-1-((diaminomethylene)amino)isoquinolin-7-yl)benzoic acid
-
 Homo sapiens
0.000083
-
 2-(4-chloro-7-(3-methoxyphenyl)isoquinolin-1-yl)guanidine
-
 Homo sapiens
0.0001
-
 2-(4-chloro-7-(2-methoxyphenyl)isoquinolin-1-yl)guanidine
-
 Homo sapiens
0.0001
-
 2-(7-(1,3-benzodioxol-5-yl)-4-chloroisoquinolin-1-yl)guanidine
-
 Homo sapiens
0.00018
-
 2-(4-chloro-7-(2-cyano-6-methoxyphenyl)isoquinolin-1-yl)guanidine
-
 Homo sapiens
0.00034
-
 2-(7-(1,3-benzodioxol-5-yl)isoquinolin-1-yl)guanidine
-
 Homo sapiens
0.0004
-
 2-(7-phenylisoquinolin-1-yl)guanidine
-
 Homo sapiens