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Literature summary for 3.4.21.73 extracted from
- Implication of cysteine residues in the activity of single-chain urokinase-plasminogen activator (1993), Biochem. Biophys. Res. Commun., 194, 978-985.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| plasminogen + H2O | Homo sapiens | key enzyme in the thrombolytic cascade converting plasminogen into plasmin, which in turn degrades thrombus fibrin | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
single-chain uPA | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | disulfide bridges in the catalytic domain are essential for maintaining amidolytic and fibrinolytic activity | Homo sapiens | ? | - |
? | |
| plasminogen + H2O | - |
Homo sapiens | plasmin + ? | - |
? | |
| plasminogen + H2O | key enzyme in the thrombolytic cascade converting plasminogen into plasmin, which in turn degrades thrombus fibrin | Homo sapiens | ? | - |
? | |
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Release 2023.1 (January 2023)
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