Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ecotin | inhibits uPA almost 10000-fold less efficiently than trypsin, ecotin is expressed on the surface of filamentous bacteriophage, each of the selected ecotin variants (M84R, M84K, M84R/M85R and M84R/M85K) exhibits increased affinity for uPA when compared to wild-type ecotin, with ecotin M84R/M85R showing 2800-fold increase in binding affinity | Homo sapiens | |
Trypsin | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
commercial preparation of low-molecular weight uPA from American Diagnostica | - |
Mammalia | - |
commercial preparation of low-molecular weight uPA from American Diagnostica | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | - |
Homo sapiens | plasmin + ? | - |
? |