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Literature summary for 3.4.21.73 extracted from

  • Takahashi, K.; Kwaan, H.C.; Koh, E.; Tanabe, M.
    Enzymatic properties of the phosphorylated urokinase-type plasminogen activator isolated from a human carcinomatous cell line (1992), Biochem. Biophys. Res. Commun., 182, 1473-1481.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
concanavalin A
-
Homo sapiens
plasminogen activator inhibitor 1 phosphorylated uPA is less sensitive to inhibition than nonphosphorylated uPA Homo sapiens
Plasminogen activator inhibitor 2
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000243
-
plasminogen pH 7.5, nonphosphorylated uPA Homo sapiens
0.017
-
plasminogen pH 7.5, phosphorylated uPA Homo sapiens
0.297
-
L-diglutamyl-glycyl-L-arginine-4-nitroanilide pH 8.8, phosphorylated uPA Homo sapiens
0.392
-
L-diglutamyl-glycyl-L-arginine-4-nitroanilide pH 7.5, phosphorylated uPA Homo sapiens
0.438
-
L-diglutamyl-glycyl-L-arginine-4-nitroanilide pH 8.8, nonphosphorylated uPA Homo sapiens
0.608
-
L-diglutamyl-glycyl-L-arginine-4-nitroanilide pH 7.5, nonphosphorylated uPA Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell
-
Homo sapiens
-
Detroit 562 cell
-
Homo sapiens
-
ECV304 cell
-
Homo sapiens
-
urine
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-diglutamyl-glycyl-L-arginine-4-nitroanilide + H2O
-
Homo sapiens L-diglutamyl-glycyl-L-arginine + 4-nitroaniline
-
?
plasminogen + H2O
-
Homo sapiens plasmin + ? generation of 2 polypeptides, one of 80000 MW (A-chain), and the other of 27000 MW (B-chain) ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0075
-
L-diglutamyl-glycyl-L-arginine-4-nitroanilide pH 8.8, nonphosphorylated uPA Homo sapiens
0.0113
-
L-diglutamyl-glycyl-L-arginine-4-nitroanilide pH 7.5, nonphosphorylated uPA Homo sapiens
0.0383
-
plasminogen pH 7.5, nonphosphorylated uPA Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 9.5 phosphorylated uPA Homo sapiens
8.8 9.5 nonphosphorylated uPA Homo sapiens