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Literature summary for 3.4.21.7 extracted from

  • Mhashilkar, A.M.; Viswanatha, T.; Chibber, B.A.K.; Castellino, F.J.
    Breaching the conformational integrity of the catalytic triad of the serine protease plasmin: localized disruption of a side chain of His-603 strongly inhibits the amidolytic activity of human plasmin (1993), Proc. Natl. Acad. Sci. USA, 90, 5374-5377.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
mutant enzyme P611I expressed in recombinant baculovirus-infected Spodoptera frugiperda cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
P611I mutant enzyme has no amidolytic activity with D-Val-Leu-Lys-p-nitroanilide Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Val-Leu-Lys-p-nitroanilide + H2O
-
Homo sapiens D-Val-Leu-Lys + p-nitroaniline
-
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