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Literature summary for 3.4.21.7 extracted from
- Natural and engineered plasmin inhibitors: applications and design strategies (2012), ChemBioChem, 13, 336-348.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| urokinase-type plasminogen activator | converts plasminogen bound to a plasminogen receptor into plasmin | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 6-aminohexanoate | - |
Homo sapiens |  |
| Aedes aegypti trypsin inhibitor | - |
Homo sapiens | |
| alpha-antiplasmin | potent inhibitor | Homo sapiens | |
| amyloid precursor-like protein 2 | - |
Homo sapiens | |
| Aprotinin | - |
Homo sapiens | |
| bdellin | - |
Homo sapiens | |
| bikazin salivary inhibitor | - |
Homo sapiens | |
| bikunin | - |
Homo sapiens | |
| chicken liver trypsin inhibitor | - |
Homo sapiens | |
| CU-2010 | potent inhibitpr | Homo sapiens | |
| D-Ile-Phe-Lys-CH2Cl | - |
Homo sapiens | |
| DX-1000 | - |
Homo sapiens | |
| infestin | - |
Homo sapiens | |
| KD1-L17R | - |
Homo sapiens | |
| KM(O2)YR-H | - |
Homo sapiens | |
| Kunitz-type inhibitor 2 | - |
Homo sapiens | |
| Leucaena-type trypsin inhibitor | - |
Homo sapiens | |
| nexin 2 | - |
Homo sapiens | |
| ONO-3307 | i.e. 4-sulfamoyl phenyl-4-guanidinobenzoate methanesulfonate | Homo sapiens | |
| plasminostreptin | - |
Homo sapiens | |
| TdPI tryptase inhibitor | - |
Homo sapiens | |
| textilinin-1 | - |
Homo sapiens | |
| tissue factor pathway inhibitor-1 | - |
Homo sapiens | |
| tissue factor pathway inhibitor-2 | - |
Homo sapiens | |
| Tranexamic acid | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Fibrin + H2O | Homo sapiens | - |
? | - |
? | |
| MT1-matrix metalloproteinase + H2O | Homo sapiens | - |
? | - |
? | |
| pro-matrix metalloproteinase-1 + H2O | Homo sapiens | - |
matrix metalloproteinase-1 + ? | - |
? | |
| pro-matrix metalloproteinase-10 + H2O | Homo sapiens | - |
matrix metalloproteinase-10 + ? | - |
? | |
| pro-matrix metalloproteinase-13 + H2O | Homo sapiens | - |
matrix metalloproteinase-13 + ? | - |
? | |
| pro-matrix metalloproteinase-3 + H2O | Homo sapiens | - |
matrix metalloproteinase-3 + ? | - |
? | |
| pro-matrix metalloproteinase-9 + H2O | Homo sapiens | - |
matrix metalloproteinase-9 + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P00747 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Ac-KM(O2)YR + H2O | - |
Homo sapiens | ? | - |
? | |
| Ac-RM(O2)YR + H2O | - |
Homo sapiens | ? | - |
? | |
| Fibrin + H2O | - |
Homo sapiens | ? | - |
? | |
| MT1-matrix metalloproteinase + H2O | - |
Homo sapiens | ? | - |
? | |
| pro-matrix metalloproteinase-1 + H2O | - |
Homo sapiens | matrix metalloproteinase-1 + ? | - |
? | |
| pro-matrix metalloproteinase-10 + H2O | - |
Homo sapiens | matrix metalloproteinase-10 + ? | - |
? | |
| pro-matrix metalloproteinase-13 + H2O | - |
Homo sapiens | matrix metalloproteinase-13 + ? | - |
? | |
| pro-matrix metalloproteinase-3 + H2O | - |
Homo sapiens | matrix metalloproteinase-3 + ? | - |
? | |
| pro-matrix metalloproteinase-9 + H2O | - |
Homo sapiens | matrix metalloproteinase-9 + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| mu-plasminogen | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000000087 | - |
DX-1000 | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00000018 | - |
Aprotinin | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00000032 | - |
Leucaena-type trypsin inhibitor | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00000049 | - |
plasminostreptin | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0000009 | - |
KD1-L17R | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00000104 | - |
Kunitz-type inhibitor 2 | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0000011 | - |
infestin | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00000156 | - |
bdellin | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0000022 | - |
CU-2010 | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0000031 | - |
KM(O2)YR-H | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0000035 | - |
textilinin-1 | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0000038 | - |
Aedes aegypti trypsin inhibitor | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00001 | - |
tissue factor pathway inhibitor-2 | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000026 | - |
tissue factor pathway inhibitor-1 | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000042 | - |
nexin 2 | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000055 | - |
TdPI tryptase inhibitor | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000081 | - |
amyloid precursor-like protein 2 | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0001 | - |
bikunin | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000127 | - |
chicken liver trypsin inhibitor | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00033 | - |
ONO-3307 | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00057 | - |
D-Ile-Phe-Lys-CH2Cl | pH and temperature not specified in the publication | Homo sapiens | |
| 0.002 | - |
bikazin salivary inhibitor | pH and temperature not specified in the publication | Homo sapiens |
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