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Literature summary for 3.4.21.7 extracted from

  • Alves, N.J.; Kline, J.A.
    Comparative study on the inhibition of plasmin and delta-plasmin viabenzamidine derivatives (2015), Biochem. Biophys. Res. Commun., 457, 358-362.
    View publication on PubMed
Search for more literature for 3.4.21.7

Inhibitors

Inhibitors Comment Organism Structure
4-aminobenzamidine competitive inhibition Homo sapiens
4-aminomethylbenzamidine competitive inhibition Homo sapiens
4-carboxybenzamidine competitive inhibition Homo sapiens
benzamidine competitive inhibition Homo sapiens
Pentamidine competitive inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.269
-
 D-Val-L-Leu-L-Lys-4-nitroanilide full-length plasmin, in phosphate buffered saline, pH 7.4, at 25°C Homo sapiens
0.325
-
 D-Val-L-Leu-L-Lys-4-nitroanilide truncated delta-plasmin, in phosphate buffered saline, pH 7.4, at 25°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
91000
-
 x * 91000, plasminogen, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Fibrin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Val-L-Leu-L-Lys-4-nitroanilide + H2O
-
 Homo sapiens D-Val-L-Leu-L-Lys + 4-nitroaniline
-
 ?
Fibrin + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 91000, plasminogen, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
delta-plasmin a truncated non-glycosylated plasmin variant Homo sapiens
plasminogen pro-enzyme Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
12.8
-
 D-Val-L-Leu-L-Lys-4-nitroanilide full-length plasmin, in phosphate buffered saline, pH 7.4, at 25°C Homo sapiens
12.97
-
 D-Val-L-Leu-L-Lys-4-nitroanilide truncated delta-plasmin, in phosphate buffered saline, pH 7.4, at 25°C Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0022
-
 Pentamidine full-length plasmin, in phosphate buffered saline, pH 7.4, at 25°C Homo sapiens
0.004
-
 Pentamidine truncated delta-plasmin, in phosphate buffered saline, pH 7.4, at 25°C Homo sapiens
0.032
-
 benzamidine full-length plasmin, in phosphate buffered saline, pH 7.4, at 25°C Homo sapiens
0.051
-
 4-aminobenzamidine full-length plasmin, in phosphate buffered saline, pH 7.4, at 25°C Homo sapiens
0.061
-
 4-aminobenzamidine truncated delta-plasmin, in phosphate buffered saline, pH 7.4, at 25°C Homo sapiens
0.161
-
 benzamidine truncated delta-plasmin, in phosphate buffered saline, pH 7.4, at 25°C Homo sapiens
0.292
-
 4-carboxybenzamidine full-length plasmin, in phosphate buffered saline, pH 7.4, at 25°C Homo sapiens
0.301
-
 4-carboxybenzamidine truncated delta-plasmin, in phosphate buffered saline, pH 7.4, at 25°C Homo sapiens
1.074
-
 4-aminomethylbenzamidine full-length plasmin, in phosphate buffered saline, pH 7.4, at 25°C Homo sapiens
1.408
-
 4-aminomethylbenzamidine truncated delta-plasmin, in phosphate buffered saline, pH 7.4, at 25°C Homo sapiens