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Literature summary for 3.4.21.7 extracted from

  • Okunishi, K.; Sisson, T.H.; Huang, S.K.; Hogaboam, C.M.; Simon, R.H.; Peters-Golden, M.
    Plasmin overcomes resistance to prostaglandin E2 in fibrotic lung fibroblasts by reorganizing protein kinase A signaling (2011), J. Biol. Chem., 286, 32231-32243.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
urokinase-type plasminogen activator cleaves plasminogen to give active plasmin Mus musculus
urokinase-type plasminogen activator cleaves plasminogen to give active plasmin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
plasminogen activator inhibitor I inhibits plasminogen activation to plasmin by urokinase-type plasminogen activator Homo sapiens
plasminogen activator inhibitor I inhibits plasminogen activation to plasmin by urokinase-type plasminogen activator Mus musculus
plasminogen activator inhibitor II inhibits plasminogen activation to plasmin by urokinase-type plasminogen activator Homo sapiens
plasminogen activator inhibitor II inhibits plasminogen activation to plasmin by urokinase-type plasminogen activator Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Mus musculus C57BL/6
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification urokinase-type plasminogen activator cleaves plasminogen to give active plasmin Mus musculus
proteolytic modification urokinase-type plasminogen activator cleaves plasminogen to give active plasmin Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Homo sapiens
-

General Information

General Information Comment Organism
malfunction the plasminogen activation system is impaired in idiopathic pulmonary fibrosis Mus musculus
malfunction the plasminogen activation system is impaired in idiopathic pulmonary fibrosis Homo sapiens
additional information plasminogen activation to plasmin restores lipid mediator prostaglandin E2 sensitivity in fibrotic lung fibroblasts involving amplified protein kinase A signaling resulting from the promotion of new interactions between AKAP9 and protein kinase A regulatory subunit II in the perinuclear region as well as from the inhibition of protein phosphatase 2A Mus musculus
additional information plasminogen activation to plasmin restores lipid mediator prostaglandin E2 sensitivity in fibrotic lung fibroblasts involving amplified protein kinase A signaling resulting from the promotion of new interactions between AKAP9 and protein kinase A regulatory subunit II in the perinuclear region as well as from the inhibition of protein phosphatase 2A Homo sapiens
physiological function the plasminogen activation system, in which plasminogen is cleaved to plasmin, comprises an anti-fibrotic pathway that both suppresses the development of pulmonary fibrosis in vivo Mus musculus
physiological function the plasminogen activation system, in which plasminogen is cleaved to plasmin, comprises an anti-fibrotic pathway that both suppresses the development of pulmonary fibrosis in vivo Homo sapiens