Activating Compound | Comment | Organism | Structure |
---|---|---|---|
urokinase-type plasminogen activator | cleaves plasminogen to give active plasmin | Mus musculus | |
urokinase-type plasminogen activator | cleaves plasminogen to give active plasmin | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
plasminogen activator inhibitor I | inhibits plasminogen activation to plasmin by urokinase-type plasminogen activator | Homo sapiens | |
plasminogen activator inhibitor I | inhibits plasminogen activation to plasmin by urokinase-type plasminogen activator | Mus musculus | |
plasminogen activator inhibitor II | inhibits plasminogen activation to plasmin by urokinase-type plasminogen activator | Homo sapiens | |
plasminogen activator inhibitor II | inhibits plasminogen activation to plasmin by urokinase-type plasminogen activator | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Mus musculus C57BL/6 | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | urokinase-type plasminogen activator cleaves plasminogen to give active plasmin | Mus musculus |
proteolytic modification | urokinase-type plasminogen activator cleaves plasminogen to give active plasmin | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
malfunction | the plasminogen activation system is impaired in idiopathic pulmonary fibrosis | Mus musculus |
malfunction | the plasminogen activation system is impaired in idiopathic pulmonary fibrosis | Homo sapiens |
additional information | plasminogen activation to plasmin restores lipid mediator prostaglandin E2 sensitivity in fibrotic lung fibroblasts involving amplified protein kinase A signaling resulting from the promotion of new interactions between AKAP9 and protein kinase A regulatory subunit II in the perinuclear region as well as from the inhibition of protein phosphatase 2A | Mus musculus |
additional information | plasminogen activation to plasmin restores lipid mediator prostaglandin E2 sensitivity in fibrotic lung fibroblasts involving amplified protein kinase A signaling resulting from the promotion of new interactions between AKAP9 and protein kinase A regulatory subunit II in the perinuclear region as well as from the inhibition of protein phosphatase 2A | Homo sapiens |
physiological function | the plasminogen activation system, in which plasminogen is cleaved to plasmin, comprises an anti-fibrotic pathway that both suppresses the development of pulmonary fibrosis in vivo | Mus musculus |
physiological function | the plasminogen activation system, in which plasminogen is cleaved to plasmin, comprises an anti-fibrotic pathway that both suppresses the development of pulmonary fibrosis in vivo | Homo sapiens |