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Literature summary for 3.4.21.7 extracted from

  • Venkatraman, L.; Li, H.; Dewey Jr., C.; White, J.; Bhowmick, S.; Yu, H.; Tucker-Kellogg, L.
    Steady states and dynamics of urokinase-mediated plasmin activation in silico and in vitro (2011), Biophys. J., 101, 1825-1834.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.7

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information although neither plasmin nor urokinase-type plasminogen activator exhibits allosteric cooperativity, modeling shows that cooperativity occurs at the system level because of substrate competition, molecular modeling and simulation, substrate competition and bistability, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification cleavage of plasminogen to active plasmin by urokinase-type plasminogen activator, complex dynamics and mathematical modeling, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Val-Leu-Lys-4-nitroanilide + H2O
-
 Homo sapiens D-Val-Leu-Lys + 4-nitroaniline
-
 ?
additional information substrate competition with urokinase-type plasminogen activator and bistability, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PLS
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function plasmin and urokinase-type plasminogen activator are ubiquitous proteases that regulate the extracellular environment. Although neither plasmin nor urokinase-type plasminogen activator exhibits allosteric cooperativity, modeling shows that cooperativity occurs at the system level because of substrate competition Homo sapiens