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Literature summary for 3.4.21.7 extracted from

  • Sun, Z.; Lu, W.; Jiang, A.; Chen, J.; Tang, F.; Liu, J.N.
    Expression, purification and characterization of aprotinin and a human analogue of aprotinin (2009), Protein Expr. Purif., 65, 238-243.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
human aprotinin analogue
-
Homo sapiens
natural aprotinin
-
Homo sapiens
recombinant aprotinin
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-valyl-L-leucyl-L-lysine-4-nitroanilide + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
plasmin
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000075
-
natural aprotinin
-
Homo sapiens
0.0000086
-
recombinant aprotinin
-
Homo sapiens
0.0000227
-
human aprotinin analogue compared with recombinant-aprotinin, the Ki of the human aprotinin analogue is found to increase by about 2.6fold, suggesting that the substitution of Arg17-Ile18 with Lys17-Met18 in aprotinin somehow impair its interaction with plasmin Homo sapiens