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Literature summary for 3.4.21.7 extracted from

  • Passero, C.J.; Mueller, G.M.; Rondon-Berrios, H.; Tofovic, S.P.; Hughey, R.P.; Kleyman, T.R.
    Plasmin activates epithelial Na+ channels by cleaving the gamma subunit (2008), J. Biol. Chem., 283, 36586-36591.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
epithelial sodium channel gamma subunit + H2O Bos taurus plasmin activates epithelial sodium channels in association with inducing cleavage of the gamma subunit at gammaLys194, a site distal to the furin site. A gammaK194A mutant epithelial sodium channel subunit prevents both plasmin-dependent activation of epithelial sodium channel and plasmin-dependent production of a unique 70-kDa carboxyl-terminal gamma subunit cleavage fragment ?
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Organism

Organism UniProt Comment Textmining
Bos taurus
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
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 Bos taurus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
epithelial sodium channel gamma subunit + H2O plasmin activates epithelial sodium channels in association with inducing cleavage of the gamma subunit at gammaLys194, a site distal to the furin site. A gammaK194A mutant epithelial sodium channel subunit prevents both plasmin-dependent activation of epithelial sodium channel and plasmin-dependent production of a unique 70-kDa carboxyl-terminal gamma subunit cleavage fragment Bos taurus ?
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 ?