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Literature summary for 3.4.21.7 extracted from

  • Mannaioni, G.; Orr, A.G.; Hamill, C.E.; Yuan, H.; Pedone, K.H.; McCoy, K.L.; Berlinguer Palmini, R.; Junge, C.E.; Lee, C.J.; Yepes, M.; Hepler, J.R.; Traynelis, S.F.
    Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1 (2008), J. Biol. Chem., 283, 20600-20611.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus plasmin may serve as an endogenous PAR1 activator that can increase Ca2+ concentration, in astrocytes and potentiate N-methyl-D-aspartate receptor synaptic currents in CA1 pyramidal neurons ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte plasmin evokes an increase in both phosphoinositide hydrolysis and Fura-2/AM fluorescence in cultured cortical astrocytes. Plasmin activiates extracellular signal-regulated kinase and induces a rise in intracellular Ca2+ concentration and phopho-ERK1/2 levels Mus musculus
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hippocampus plasmin has no effect on ERK1/2 signaling or Ca2+ concentraion in primary cultured hippocampal neurons or hippocampal slices Mus musculus
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pyramidal neuron in CA1 pyramidal neuron, plasmin application potentiates the N-methyl-D-aspartate receptor-dependent component of miniature excitatory postsynaptic currents recorded from CA1 pyramidal neurons but has no effect on -amino-3-hydroxy-5-methyl-4-isoxazole propionate- or -aminobutyric acid receptor-mediated synaptic currents. Plasmin also increased N-methyl-D-aspartate-induced whole cell receptor currents recorded from CA1 pyramidal cells Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information plasmin may serve as an endogenous PAR1 activator that can increase Ca2+ concentration, in astrocytes and potentiate N-methyl-D-aspartate receptor synaptic currents in CA1 pyramidal neurons Mus musculus ?
-
 ?