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Literature summary for 3.4.21.7 extracted from

  • Nogami, K.; Shima, M.; Matsumoto, T.; Nishiya, K.; Tanaka, I.; Yoshioka, A.
    Mechanisms of plasmin-catalyzed inactivation of factor VIII: a crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation (2007), J. Biol. Chem., 282, 5287-5295.
    View publication on PubMed

Application

Application Comment Organism
degradation cleavage at Arg336 is a central mechanism of plasmin-catalyzed factor VIII inactivation. Cleavages at Arg336 and Lys36 are selectively regulated by the A2 and A3-C1-C2 domains, respectively, interacting with plasmin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
pefabloc
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Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor VIII + H2O cleaves the heavy chain of factor VIII into two terminal products, A137–336 and A2 subunits, by limited proteolysis at Lys36, Arg336, Arg372, and Arg740. The 80-kDa light chain is converted into a 67-kDa subunit by cleavage at Arg1689 and Arg1721 Homo sapiens ?
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