Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activation of a low concentration of plasminogen by cell-associated plasminogen activators produces sufficient active plasmin to rapidly and efficiently process pro-brain-derived neurotrophic factor in the pericellular environment | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | processing of pro-brain-derived neurotrophic factor by plasmin stimulates neurite outgrowth on TrkB-transfected PC-12 cells to a similar extent than mature wild-type brain-derived neurotrophic factor | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | in PC-3 cells, processing of pro-brain-derived neurotrophic factor by plasmin occurs in the pericellular environment | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-brain-derived neurotrophic factor + H2O | plasmin is a specific and efficient activator of pro-brain-derived neurotrophic factor. The pro-form is rapidly processed to an 18 kDa fragment at a low concentration of plasmin. This C-terminal fragment is equivalent in size to the furin-processed, mature form of wild-type brain-derived neurotrophic factor. The proteolytic cleavage site is Arg125-Val126, within the consensus furin-cleavage motif | Homo sapiens | ? | - |
? |