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Literature summary for 3.4.21.7 extracted from

  • Biswas, N.; Vaingankar, S.M.; Mahata, M.; Das, M.; Gayen, J.R.; Taupenot, L.; Torpey, J.W.; OConnor, D.T.; Mahata, S.K.
    Proteolytic cleavage of human chromogranin a containing naturally occurring catestatin variants: differential processing at catestatin region by plasmin (2008), Endocrinology, 149, 749-757.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine less efficient proteolytic processing of the Pro370Leu protein by plasmin, coupled with the strong association of this variant with ethnicity, contributes to the differential prevalence of cardiovascular disease across ethnic groups Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chromogranin A + H2O chromogranin A-wild-type, chromogranin A-Gly364Ser and chromogranin A-Arg374Gln completely digested with plasmin at 0.0004 mM Homo sapiens catestatin + ?
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additional information plasmin is 3-4fold less efficient in processing of the chromogranin A-Pro370Leu variant as compared to wild-type and the other varinats due to less efficient cleavage between Arg373-Arg374 Homo sapiens ?
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