Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Aprotinin | augments binding of hepatocytes from mice to immobilized plasmin | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | the plasminogen/plasmin system decreases Bim(EL) expression and activation of caspase-3 via the ERK1/2 signaling pathway during liver regeneration, resulting in an enhancement of cell survival. Plasmin protects against starvation-induced apoptosis in primary hepatocytes of mice | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Aprotinin | inhibits plasmin-induced phosphorylation of ERK1/2 | Homo sapiens | |
diisopropyl fluorophosphate | does not block binding of hepatocytes from mice to immobilized plasmin, but blocks active site of plasmin and its ability to phosphorylate ERK1/2 | Homo sapiens | |
epsilon-aminocaproic acid | inhibits plasmin-induced phosphorylation of ERK1/2; lysine binding sites inhibitor, partially blocks binding of hepatocytes from mice to immobilized plasmin at 10 mM, but not at 0.01 mM | Homo sapiens | |
MG-132 | prevents facilitation of degradation of Bim(EL) by plasmin in hepatocytes from mice pretreated with cycloheximide | Homo sapiens | |
PD98059 | MEK inhibitor, completely abolishes plasmin-induced phosphorylation of ERK1/2 at 0.05 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | plasmin triggeres phosphorylation of ERK1/2 in a concentration-dependent manner, but not of Akt | Homo sapiens | ? | - |
? |