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Literature summary for 3.4.21.7 extracted from

  • Fujiyoshi, T.; Hirano, K.; Hirano, M.; Nishimura, J.; Takahashi, S.; Kanaide, H.
    Plasmin Induces Endothelium-Dependent Nitric Oxide-Mediated Relaxation in the Porcine Coronary Artery (2007), Arterioscler. Thromb. Vasc. Biol., 27, 949-954.
    View publication on PubMed
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Application

Application Comment Organism
medicine plasmin induces an endothelium-dependent NO-mediated vasorelaxation in the porcine coronary artery, whereas it inhibits the endothelium-dependent relaxation induced by thrombin Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
4-amidinophenyl methane-sulfonyl fluoride abolishes plasmin-induced Ca2+ elevation by its pretreatment of plasmin Homo sapiens
4-amidinophenyl methane-sulfonyl fluoride substantially abrogates the relaxing effect of plasmin. Abolishes plasmin-induced Ca2+ elevation by its pretreatment of plasmin Sus scrofa
additional information pretreatment with plasmin, thrombin and trypsin significantly but, only partly, attenuates subsequent relaxation induced by plasmin. Major part of the plasmin-induced relaxation is resistant to these pretreatments Sus scrofa
Nomega-nitro-L-arginine methyl ester almost completely abolishes plasmin-induced relaxation Sus scrofa
Tranexamic acid substantially abrogates the relaxing effect of plasmin Sus scrofa

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Sus scrofa
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Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell plasmin induces a concentration-dependent transient elevation in the cytosolic Ca2+ concentrations Homo sapiens
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additional information in PCAEC cells, plasmin induces an endothelium-dependent relaxation and a concentration-dependent transient elevation in the cytosolic Ca2+ concentrations. Plasmin concentration-dependently induces NO production Sus scrofa
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