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Literature summary for 3.4.21.7 extracted from

  • Lauer, G.; Sollberg, S.; Cole, M.; Krieg, T.; Eming, S.A.
    Generation of a novel proteolysis resistant vascular endothelial growth factor165 variant by a site-directed mutation at the plasmin sensitive cleavage site (2002), FEBS Lett., 531, 309-313.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
vascular endothelial growth factor + H2O Homo sapiens in non-healing wounds plasmin cleaves and inactivates vascular endothelial growth factor VEGF165 ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
vascular endothelial growth factor + H2O cleavage site: Arg110-/-Ala111. The mutant vascular endothelial growth factors R110A, R110Q and A111P are resistant to cleavage Homo sapiens ?
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vascular endothelial growth factor + H2O in non-healing wounds plasmin cleaves and inactivates vascular endothelial growth factor VEGF165 Homo sapiens ?
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?