Literature summary for 3.4.21.69 extracted from

Luo, L.; Lv, T.; Wang, Q.; Zhang, T.; Gu, X.; Xu, F.; Song, Y.
Activated protein C induces endoplasmic reticulum stress and attenuates lipopolysaccharide-induced apoptosis mediated by glycogen synthase kinase-3beta (2012), Mediators Inflamm., 2012, 485279.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
umbilical vein endothelial cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Activated protein C	-	Homo sapiens
APC	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	activated protein C induces endoplasmic reticulum stress and attenuates lipopolysaccharide-induced apoptosis both mediated by glycogen synthase kinase-3beta. Activated protein C elicits a rise in glucose-regulated protein 78 and glycogen synthase kinase-3beta and inhibits apoptosis in human umbilical vein endothelial cells induced by lipopolysaccharide. Calcium inhibition does not alter the antiapoptotic effect of activated protein C	Homo sapiens

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Release 2023.1 (January 2023)