Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ProTac | a protein C-activating agent | Homo sapiens | |
ProTac | a protein C-activating agent | Bos taurus | |
ProTac | a protein C-activating agent isolated from snake venom, administration to mice enhances the production of octanoyl ghrelin(1-15) in circulation | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ProTac | a protein C activator isolated from snake venom | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ghrelin + H2O | Mus musculus | ghrelin is converted into smaller fragments in blood plasma in circulation under thrombotic and inflammatory conditions | ? | - |
? | |
ghrelin + H2O | Homo sapiens | ghrelin is converted into smaller fragments in blood plasma in circulation under thrombotic and inflammatory conditions | ? | - |
? | |
ghrelin + H2O | Bos taurus | ghrelin is converted into smaller fragments in blood plasma in circulation under thrombotic and inflammatory conditions | ? | - |
? | |
ghrelin + H2O | Mus musculus C57/BL6J | ghrelin is converted into smaller fragments in blood plasma in circulation under thrombotic and inflammatory conditions | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Mus musculus C57/BL6J | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme from bovine plasma by gel filtration, mannose affinity and Blue Sepharose chromatography | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Mus musculus | - |
blood plasma | - |
Homo sapiens | - |
blood plasma | - |
Bos taurus | - |
commercial preparation | from plasma | Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
57.3 | - |
purified native enzyme, amidolytic activity, pH 8.0, 37°C | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Boc-Leu-Ser-Thr-Arg-4-nitroanilide + H2O | - |
Mus musculus | Boc-Leu-Ser-Thr-Arg + 4-nitroaniline | - |
? | |
Boc-Leu-Ser-Thr-Arg-4-nitroanilide + H2O | amidolytic activity | Bos taurus | Boc-Leu-Ser-Thr-Arg + 4-nitroaniline | - |
? | |
Boc-Leu-Ser-Thr-Arg-4-nitroanilide + H2O | - |
Mus musculus C57/BL6J | Boc-Leu-Ser-Thr-Arg + 4-nitroaniline | - |
? | |
ghrelin + H2O | ghrelin is converted into smaller fragments in blood plasma in circulation under thrombotic and inflammatory conditions | Mus musculus | ? | - |
? | |
ghrelin + H2O | ghrelin is converted into smaller fragments in blood plasma in circulation under thrombotic and inflammatory conditions | Homo sapiens | ? | - |
? | |
ghrelin + H2O | ghrelin is converted into smaller fragments in blood plasma in circulation under thrombotic and inflammatory conditions | Bos taurus | ? | - |
? | |
ghrelin + H2O | ghrelin is converted into smaller fragments in blood plasma in circulation under thrombotic and inflammatory conditions | Mus musculus C57/BL6J | ? | - |
? | |
additional information | both acyl and desacyl ghrelin are hydrolyzed at the peptide bond between Arg15 and Lys16, generating an N-terminal peptide consisting of the first 15 residues | Mus musculus | ? | - |
? | |
additional information | both acyl and desacyl ghrelin are hydrolyzed at the peptide bond between Arg15 and Lys16, generating an N-terminal peptide consisting of the first 15 residues | Homo sapiens | ? | - |
? | |
additional information | bovine enzyme preferentially hydrolyzes the major form of octanoylated ghrelin(28), i.e. about twice as much hydrolysis as is observed for a longer acyl chain of decanoylated ghrelin(28). But both acyl and desacyl ghrelin are hydrolyzed at the peptidebond between Arg15 and Lys16, generating an N-terminal peptide consisting of the first 15 residues | Bos taurus | ? | - |
? | |
additional information | both acyl and desacyl ghrelin are hydrolyzed at the peptide bond between Arg15 and Lys16, generating an N-terminal peptide consisting of the first 15 residues | Mus musculus C57/BL6J | ? | - |
? | |
octanoyl-ghrelin + H2O | - |
Homo sapiens | ? | - |
? | |
octanoyl-ghrelin + H2O | - |
Bos taurus | ? | - |
? | |
octanoyl-ghrelin + H2O | preferred substrate | Mus musculus | octanoyl ghrelin(1-15) + ? | - |
? | |
octanoyl-ghrelin + H2O | preferred substrate | Mus musculus C57/BL6J | octanoyl ghrelin(1-15) + ? | - |
? | |
octanoyl-truncated ghrelin + H2O | preferred substrate, synthetic human substrate, octanoyl-truncated ghrelin(1-15) activates GHSR1a-dependent signaling similar to the full-length peptide | Homo sapiens | ? | - |
? | |
octanoyl-truncated ghrelin + H2O | preferred substrate, synthetic human substrate, octanoyl-truncated ghrelin(1-15) activates GHSR1a-dependent signaling similar to the full-length peptide | Bos taurus | ? | - |
? | |
octanoyl-truncated ghrelin + H2O | octanoyl-truncated ghrelin(1-15) activates GHSR1a-dependent signaling similar to the full-length peptide | Mus musculus | ghrelin(1-15) + ? | - |
? | |
octanoyl-truncated ghrelin + H2O | octanoyl-truncated ghrelin(1-15) activates GHSR1a-dependent signaling similar to the full-length peptide | Mus musculus C57/BL6J | ghrelin(1-15) + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Activated protein C | - |
Mus musculus |
Activated protein C | - |
Homo sapiens |
Activated protein C | - |
Bos taurus |
anticoagulant serine protease-activated protein C | - |
Mus musculus |
anticoagulant serine protease-activated protein C | - |
Homo sapiens |
anticoagulant serine protease-activated protein C | - |
Bos taurus |
APC | - |
Mus musculus |
APC | - |
Homo sapiens |
APC | - |
Bos taurus |
ghrelin endopeptidase | - |
Mus musculus |
ghrelin endopeptidase | - |
Homo sapiens |
ghrelin endopeptidase | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Mus musculus |
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Mus musculus |
8 | - |
assay at | Bos taurus |
General Information | Comment | Organism |
---|---|---|
additional information | enzyme peptide mass fingerprinting analysis | Mus musculus |
physiological function | the enzyme is a major regulator of blood coagulation by inactivating factors Va and VIIIa. O-ghrelin(15) has no effect | Mus musculus |
physiological function | the enzyme is a major regulator of blood coagulation by inactivating factors Va and VIIIa. O-ghrelin(15) has no effect | Homo sapiens |
physiological function | the enzyme is a major regulator of blood coagulation by inactivating factors Va and VIIIa. O-ghrelin(15) has no effect | Bos taurus |